Kensuke Miyake Selected Research

Toll-Like Receptor 7

1/2021	Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes.
1/2020	Activated M2 Macrophages Contribute to the Pathogenesis of IgG4-Related Disease via Toll-like Receptor 7/Interleukin-33 Signaling.
1/2019	ADP-ribosylation factor-like 8b is required for the development of mouse models of systemic lupus erythematosus.
12/2018	Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
7/2011	Unc93B1 restricts systemic lethal inflammation by orchestrating Toll-like receptor 7 and 9 trafficking.

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Kensuke Miyake Research Topics

Disease

23	Inflammation (Inflammations) 10/2021 - 01/2002
5	Autoimmune Diseases (Autoimmune Disease) 01/2021 - 01/2009
5	Neoplasms (Cancer) 01/2021 - 01/2003
5	Infections 10/2018 - 07/2003
5	Septic Shock (Toxic Shock Syndrome) 03/2013 - 01/2003
4	Sepsis (Septicemia) 09/2013 - 01/2003
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2021 - 01/2018
3	Hypersensitivity (Allergy) 01/2019 - 02/2005
2	Bites and Stings (Sting) 10/2021 - 01/2019
2	Tick-Borne Diseases (Tick-Borne Disease) 01/2021 - 01/2020
2	Tick Infestations 01/2021 - 01/2020
2	Immunoglobulin G4-Related Disease 01/2020 - 01/2017
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2019 - 09/2003
2	Chronic Obstructive Pulmonary Disease (COPD) 12/2018 - 01/2017
2	Communicable Diseases (Infectious Diseases) 12/2018 - 10/2012
2	Hepatitis 01/2018 - 04/2006
2	Parasitic Diseases (Parasitic Disease) 01/2018 - 01/2018
2	Neoplasm Metastasis (Metastasis) 08/2013 - 11/2008
2	Colitis 06/2013 - 10/2012
2	Obesity 04/2013 - 05/2012
2	Rheumatoid Arthritis 12/2006 - 05/2004
1	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 10/2021
1	Disease Progression 01/2021
1	Atopic Dermatitis (Atopic Eczema) 10/2020
1	Pruritus (Itching) 01/2020
1	Pain (Aches) 01/2020
1	Erythema 01/2020
1	Blister (Bulla) 01/2020
1	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019
1	Emphysema 12/2018
1	Muscle Spasticity (Spastic) 01/2018
1	Hyperplasia 01/2018
1	Anaphylaxis (Anaphylactic Shock) 01/2018
1	Pulmonary Emphysema 11/2017
1	Trichohepatoenteric Syndrome 01/2017
1	Cytokine Release Syndrome 01/2017
1	Massive Hepatic Necrosis 01/2017
1	Fibrosis (Cirrhosis) 03/2016

Drug/Important Bio-Agent (IBA)

9	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2017 - 01/2002
8	CytokinesIBA 01/2020 - 07/2003
8	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2003
8	LigandsIBA 01/2019 - 01/2002
8	LipopolysaccharidesIBA 01/2012 - 01/2003
7	DNA (Deoxyribonucleic Acid)IBA 10/2021 - 04/2010
6	Interleukin-4 (Interleukin 4)IBA 01/2021 - 01/2017
6	Toll-Like Receptor 4IBA 11/2017 - 09/2002
5	RNA (Ribonucleic Acid)IBA 10/2021 - 01/2003
5	Toll-Like Receptor 7IBA 01/2021 - 07/2011
5	Immunoglobulin E (IgE)IBA 10/2020 - 05/2008
5	EndotoxinsIBA 02/2005 - 01/2003
4	Nucleic AcidsIBA 10/2021 - 08/2012
4	InterferonsIBA 10/2021 - 11/2010
3	VaccinesIBA 01/2021 - 01/2018
3	Interleukin-33IBA 01/2020 - 01/2017
3	Interferon Type IIBA 01/2019 - 11/2010
3	Double-Stranded RNA (RNA, Double Stranded)IBA 10/2018 - 05/2002
3	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 01/2017
3	Fatty Acids (Saturated Fatty Acids)IBA 03/2016 - 04/2012
3	NF-kappa B (NF-kB)IBA 11/2008 - 02/2005
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2006 - 07/2003
2	AutoantibodiesIBA 01/2021 - 04/2013
2	Immunoglobulin G (IgG)IBA 01/2020 - 01/2017
2	Phosphotransferases (Kinase)IBA 10/2018 - 02/2005
2	ChemokinesIBA 10/2018 - 07/2017
2	AntibodiesIBA 01/2018 - 06/2012
2	Messenger RNA (mRNA)IBA 01/2017 - 02/2003
2	Toll-Like Receptor 9IBA 01/2017 - 01/2013
2	GalactosamineIBA 01/2017 - 04/2006
2	Interleukin-6 (Interleukin 6)IBA 01/2016 - 12/2011
2	Lipid AIBA 10/2006 - 10/2003
1	Cadherins (E-Cadherin)IBA 01/2021
1	immune RNA (I-RNA)IBA 01/2021
1	CalciumIBA 01/2021
1	Cell Adhesion MoleculesIBA 01/2021
1	OxazoloneIBA 10/2020
1	AntigensIBA 01/2020
1	Bee Venoms (Bee Venom)IBA 01/2020
1	Azacitidine (5 Azacytidine)FDA Link 01/2019
1	Carrier Proteins (Binding Protein)IBA 01/2019
1	ADP-Ribosylation Factors (ADP-Ribosylation Factor)IBA 01/2019
1	picric acid (picrate)IBA 01/2019
1	HaptensIBA 01/2019
1	Interleukin-3 (Interleukin 3)IBA 01/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2019
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2019
1	OvalbuminIBA 01/2019
1	trinitrophenyl-bovine serum albuminIBA 01/2019
1	Bovine Serum AlbuminIBA 01/2019
1	Pancreatic Elastase (Elastase)IBA 12/2018
1	Matrix Metalloproteinases (MMPs)IBA 12/2018
1	Mechanistic Target of Rapamycin Complex 2IBA 10/2018
1	Anti-Anxiety Agents (Anxiolytics)IBA 01/2018
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2018
1	EnzymesIBA 11/2017
1	FucoseIBA 11/2017
1	FucosyltransferasesIBA 11/2017
1	Serine Proteases (Serine Protease)IBA 07/2017
1	isoliquiritigenin (GU 17)IBA 03/2016
1	FlavonoidsIBA 03/2016

Therapy/Procedure

4	Therapeutics 01/2019 - 01/2003